Journal: Frontiers in Neuroscience
Article Title: Harnessing the potential of human induced pluripotent stem cells, functional assays and machine learning for neurodevelopmental disorders
doi: 10.3389/fnins.2024.1524577
Figure Lengend Snippet: How MEA was used to study NDD with hiPSC model.
Article Snippet: MEF2C deficiency , , 2d cortical excitatory neurons (NGN2 transduction) , 48-well CytoView LD-MEA (Axion Biosystem) , Every 3 days from day 27 to day 60 , BrainPhys , N/A , Weighted MFR, spike count, synchrony, oscillation , Neurons with loss of MEF2C displayed decreased network activity and synchrony, suggesting a disruption in the synapse formation..
Techniques: Control, Transduction, Activity Assay, Disruption, Mutagenesis, Imaging, Inhibition, In Vitro